Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant
نویسندگان
چکیده
منابع مشابه
Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant.
We tested the hypothesis that induction of neuronal NO synthase (nNOS) impairs vascular smooth muscle contractility after hypoxia. nNOS protein was increased in aorta, mesenteric arterioles, pulmonary arteries, brain, and diaphragm from rats exposed to 8% O2 for 48 hours and in human aortic SMCs after hypoxic incubation (1% O2). Ca-dependent NO synthase activity was increased in endothelium-den...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2005
ISSN: 0021-9738
DOI: 10.1172/jci20806